Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development.

Belongs to the TALE/IRO homeobox family.

496 amino acids

MSYPQFGYPYSSTPQFLMTTNSLSTCCESSGRSLSDSAAAASAQTPVYCPVYESRLLATARHELNSAAALGVYGNPYTSTQGYGNYVTYGADASAFYSLNAFESKDGTGSAHAGIPQTAAYYPYEHTLSQYQYDRYGTMDGSSRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDEKRPYDEEEEEEEEEEDSQKATIKNEKKTVDEEVVREDKALDLSDLEDFDTIESESSECELKQPFHHQPQDGHQLRQRDCVNDHCKDVILKMPLNSTVNQELDRTNICLKSGVDQCEQDVLRGRQRSGESKACFQQQQILDSKPRIWSLAHTATSLNQTEYPSCMLKHQGLSSPSSSSSSSAVSTPVCVIDRRQDSPVTSLRNWVDGVFHDPLFRHSTLNQALTNTTVSWATTKGTLIDSGSLGRSVGNPTNVKGQLPNIPHDTNKEFIAFQKSGSKMFCS

55.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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