Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).

Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.

698 amino acids

MIPQLLQRSSRACPRYNPALYRLSTTSQQRPGLTQTFWTSAPRREQPRTPTDSKPTTTKPSAVFPANKKATKQNDPLVTVEKSAPEQRKADWAIMKEMTRYLWPKDDWGTKLRVSLAVSLLIGAKVLNVQVPFYFKSIVDSMNIDVAAVGGTATTVAGAMILAYGASRIGATVFQELRNAVFASVAQNAIRKVACNVFDHLLRLDLTFHLSKQTGGLTRALDRGTKGISFILSSMVFHVLPTALEISMVCGILTYNYGAKFAALTVLTMVSYTAFTIWTTAWRTKFRRQANAADNKASTVAVDSLINYEAVKYFNNEKFEVARYDKALGQYEKNSIKVATSLALLNSGQNIIFSSALTGMMYLAANGVAEGTLTVGDLVMVNQLVFQLSVPLNFLGSVYRELRQSLLDMETLFNLQKVNANIKEKAGAKPLVLSKGGEIKFENVNFAYHPNRPILRDLSLTIPAGKKVAVVGPSGCGKSTLLRLLFRSYDVQGGRVLIDDQDIRDVDLESLRRSIGVVPQDTPLFNDTVEHNIRYGSINATHEEVVAVAKRAHVHNTIQSFPDGYETKVGERGLMISGGEKQRLAVSRILLKDPPLLFFDEATSALDTHTEQALMMNINSILRERGRTSVFVAHRLRTIFDSDLIIVLKEGHVAEMGTHRELIDRDGVYAELWSAQETMFGEDGKEKSEEENDEQKKN

77.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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