Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation) (PubMed:27126188, PubMed:27656904). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27656904).

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

842 amino acids

MSYYWVALVLFTAQAFSIEGDRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRPRGELLASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIEDEESREALESLQRLDEFMDQMDNDGNPSSHTFRIDN

95.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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