Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-ATCTTCTCTTGATTAGCCCTGATCTACGG-3' after the nucleotide sequence ATTA leaving a four-base overhang and a 3'-OH.

In the C-terminal section; belongs to the LAGLIDADG endonuclease family.

630 amino acids

MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLMNPFSKDKNKNKNKKLIRNYQKMNNNNMMKTYLNNNNMIMMNMYKGNLYDIYPRSNRNYIQPNNINKELVVYGYNLESCVGMPTYTNIVKHMVGIPNNILYIMTGILLTDGWIDYTSKKDLDKKTIMEINCRFRLKQSMIHSEYLMYVFMLLSHYCMSYPKMKIAKVKGKSYNQLEFYTRSLPCFTILRYMFYNGRVKIVPNNLYDLLNYESLAHMIMCDGSFVKGGGLYLNLQSFTTKELIFIMNILKIKFNLNCTLHKSRNKYTIYMRVESVKRLFPMIYKYILPSMRYKFDIMLWQKKYNMIN

72.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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