Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

625 amino acids

MACYIYQLPSWVLDDPCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVRQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVKKAENEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRTDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNHKISQGTFADVYRGYRHGTPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLFRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSEIPSSTASPCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRKRNTSLQEVRGSVAAVEEWLRGREMLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSVSVAPWAGAATPLLPTENGEGRLRVIVRREADSSSEACVGPEPPQDVTETSWQIDINEAKRKLMENILLYKEEKLDSIELFGP

69.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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