Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5.

Belongs to the INTS14 family.

587 amino acids

MPTLIALDASLSMLRPVPGRNEHTYQSLATKGIQHLLDNLTAAGKLEHVALLSYSTTAELKVDFTRDYDQVRQAVKKVEPVDKACLMSMLKAVVSIMSPWGNQNILQVVVFTDCGLGFGNTSITGFLEAYAEKESEPEFGFLKTLANYNLNFICLGLHGDYYFTRGLAVYQQLLDKVSLKGQLFMTKPAKSSDAVEGNPNPNPNPSHKSELGRTTVFELIERLCEASYKSSEVTLKCGSYFRMEASVLLWPPTAPYEQKSHIFGREPTIRHTDQKIEVCGFLSLSDIGSPATLSRHWVLPKVEREKSGSSRRSGNLSAAAKPPKLNLDTSNPNYELEKLEADIKEFYAKDSKDTEESGDDDVTIVLKPGPQTEQQKENLCVLLHGALKMENMAALVRVGDKWYGFIYAFTDSKKKSNLMLNILPPGTNVIPWLGDLESLGFPEDLAPGETASFPVRADRRSYSQSSVVWIRQASLQSDVQKVLRHAKKMPDKTQHFYKELNRIRRAALALGFVELLEALAMLLEKECAHLSLNGASNDCTLQLQHAATELRKTSNRDMKSMIVPLQKVGASDAGSTAATAPAPAYMY

65 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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