May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

316 amino acids

MLPRLGGTALSLLPLLLLLLGTGGRGARAEVLFRCPPCTPESLAACRPPPAAPPSAGAGPAGDSRAPCELVREPGCGCCSVCARLEGERCGVYTPRCAQGLRCYPHPGSELPLQALVLGEGTCEKRRDAEYGASPEQVADNGDDAEGGLVENHVDGNVNLLGGTGGAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQGARGAHTQRMQ

33.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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