Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Belongs to the HAM1 NTPase family.

184 amino acids

MSLRKINFVTGNVKKLEEVKAILKNFEVSNVDVDLDEFQGEPEFIAERKCREAVEAVKGPVLVEDTSLCFNAMGGLPGPYIKWFLKNLKPEGLHNMLAGFSDKTAYAQCIFAYTEGLGKPIHVFAGKCPGQIVAPRGDTAFGWDPCFQPDGFKETFGEMDKDVKNEISHRAKALELLKEYFQNN

20.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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