Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis (By similarity). Component of the inner kinetochore COMA subcomplex, which connects centromere-associated proteins and the outer kinetochore (PubMed:29046335). COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Through its multiple protein-protein interactions, OKP1 acts as a molecular nexus for inner kinetochore organization (PubMed:29046335).

Belongs to the CENP-Q/OKP1 family.

383 amino acids

MSKRYLDDVLSPDTGTSDSDSSIENLNADNYRIDIVNDNARRDDIDRIQSSNLNHEPPYNLEGVFAIDDDEHGDEMVRKDSDRRQDITEDNDDSFVPDITTPPRERKRVRFGINEKGGDEEFNNVSPWDFKRLIRKFYKEQLPDTYQIRNWKRPSKDMLTNFIDLIENNIELASEEVFKQYHQELNQLYPDSEEQAKLKDSLENKVFDTTYNIKKRLKRTKVPSKIWVDNLNMEYIYAKGESIKKRYKSELDRAEAIERQLIREEEHLKSLQEKGETQAKKRKQVLSKELSELSKTMHPSLSVALSNTFGLIKDDKMSNEIYQQDKIDFNLKLKTDFSKPLISEKEENSLNGLTNAMDNNRELVNEIFGKISALLQPKKNSNE

44.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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