Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA-binding protein (TBP) and of histones H2A and H2B (By similarity).

993 amino acids

MVESKIIKLLEQVQSADPNSRIQAELGLRDLEKYHDFAAKLTDIASSGASVPLRQGSLIYLQRYIVHHWSPLFEQFQDGPIPDENVKKHVRETLLHLLVSLDNFTLIKAVAYAVSLIANVDYPDEWPEVVPAVLHLLQSTNENSINASLDVLDELVDESLVEEQFFIIAPQLASILYQFIFSAPPNDSMRMLQARGIKLFRSCLELIEIYKETKAEHVRVFLEQILPPWMDMFSHKFEVSLVDDRQVILPDSCGYFCIMGEIAMTLTKLRELFPSKLTPYVVTFVELVWNIIEKLLDPYIREVVFSDGLDDSAFGDKYPIRYLVELLLFVSVALQSKFVQNLFVSNTVPVPPLPPCIPLLVQYTQLPKHQIEVYESDVSEYIANEFSMDFASDTVRGAAISVLSAFEEHTTLPIQQSLREMSATYILNNEINWIYQEALLYACCSVDAASDDTYDDYLDPIYEAIKVRIDYSDAPILLLSRFFLFIGYFSESTVVASQFFQIIMNNLVNALQVDTVQYAAMKAIERFCSVGKVKPILSLQPMILEVLSQYASKSSDEALVLLVEAISSAVKLDCAKAAELGNSVIPLLFNLVATNASDPYICGIIEDTFEDIIHAANNYESMCEITLPELLQVLNQEDPIMVNIGATLLSCLIRAGPSPLPNGFVGYVLPPVYKITQIHSGDTELLQLSQEILKGLLEKDTPQLLETEISGSSGFQYILFILHQLLDKESDDSACFLVGPILLELADHASQMVDLQSILLSCIKRLAIAEQPRFIQSIIYVFAKLIVKDSLGMMHFLTSSLLNEQGLTAFEVLMTVWCDNFVYFSNFKNISIICIAMTKIYSFDSPLLDSVQVKGELISHSNRIITRSQSKLHPEEYSYVSVGEKILRLLSEEFVSLSKDAIVEEVSDDGADDWDDGPISAETFGLSANDVNELSKDEFSGVDNSEDEDNTDLQFYLLEFFKEAMKSNLHNINEVVFRLPQEEQDALVQIKEK

111.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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