Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throughout hyphal growth. Moreover CDC28-HGC1 phosphorylation of EFG1 represses cell separation genes during hyphal growth. Also partially controls SEP7 phosphorylation status and subsequent septin ring dynamics. Required for virulence and especially mediates dynamic adhesion to endothelium of blood vessels during circulation.

Belongs to the cyclin family.

785 amino acids

MINITKPLTPKSISQQKQQQQHPYKNISTTKSNNNPQASGSKSFVQEKYPSQLYESEIKIHNQSLAEYDLDIYDIMVNLIETNKPNLSLYKQQPYLTFTIRLKLIDFLLKMSIRLKILPFVFFKAVKIFDRYCSKRIVLLDQSQLIITTCLWIASKVMGGNNHFVNINNLDKIGHENFRTINDLGYGCGGKYLGPTERFRLPKLHELVKLCGAKCKYDQGMFKQMEVHVLNTLEWSLNDPSIEEFIIDSHEFNVININNNNEYEQTITTNDESANANANDGNEFFKIKEFLSYAALYSHDLIDTNIIELGQVIMDLINETFQLQPFDKHYQTILNCDSDHPIRFDMQRYKHIKKAVIKSVLNASDFMMKVFHSKGPQFIYQQFNLQYKLNYTTNSIIGGFGNSGYSPTTTTTTTTSDNISTTPTSSTGSTTPVSSYIGYANSRSSSVSSTSSVASSSNANTPSSSCSTTSTTPLGMTPHKRQKNYSNYSNYSNYSNSSTSLGLTNNNNNNTTISPVDSTTINSHTKNSSQLNYQYHNGGSNNNNHHHHHKPSLSVSIPPPQMHSHHHSSTVYQMVTPPNSANKNSNKSNSANNNNTTTIATTTTTTTNNNNNSQLPAPHQLSYNNYFNSPNMQPPPPMKYTPGRKQQQQQNQGQNQQQPLQLYQGDNNNNGTNTNSKFNSIAGSRAVSSSSSSAVSIASSISTNNYDKYDDDDDDDNSNDLFSSSRRFMNYSNYSSSTINGSVMSGVINNNSGNGKGNGNGGSGTPISENDSPIYTKTRLCNMIH

87.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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