Involved in the biosynthesis of the hopanoid precursor squalene (SQ) from farnesyl diphosphate (FPP). Catalyzes the third (last) step, the reduction of hydroxysqualene (HSQ) to SQ.

Belongs to the HpnE family.

417 amino acids

MPKNVHIIGAGISGLSAAVQLSNAGLPVHVYEATQQAGGRCRSFFDSATNLTIDNGNHLVLSGNQYVRNYARAIGTESGLVGPTSAKFPFVDISTVQRWQVDLGGGRLPTWVFHKARRVPDTRLWDYLKLAPILWAGADELVGNTIPCNGTLYRRLVRPLLLAALNCDPPEGSAGLAGAIVRETLLAGGEACRPLVARDGLSAVLVEPAVKLLERRGATVRLSHKLRKLAKSAEIISELDFGDDKIAVGPDDAVILAVPPRAAATLLPGLKTPTEFRAVVNAHFRFDPPVGADPILGVVGGLVEWLFAYPQRLSVTISNGDRLLDIPREEVVRVIWRDVCEAGGISGELPPWQIVCERRATFQATPEQNALRPGPVTGCKNLFLAGDWTATGLPATIEGSVRSGNRAADLALSETNT

44.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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