Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells (PubMed:21527717, PubMed:20555324). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:21527717). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:20555324, PubMed:28379943). Methylation in the germline is required for germline development and fertility, possibly by ensuring genome stability (PubMed:21527717, PubMed:12242227). May act redundantly with mes-3 and mes-4 proteins in the development of a fertile germline (PubMed:11729150). Required for RNAi (PubMed:17967446). Functions as an antagonist of hpl-1 and hpl-2 activity in growth and somatic gonad development (PubMed:17967446). Cooperates with jmjd-3.1 and egl-27 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

1507 amino acids

MSTHDMNHHPPRKSHSKRDKPSSSNSGPKIENHKCKWAWQKVFETGKSFLRRDGFPQDCKSKEDFERIKRTGVRKTSENMLEDPRKNFESLQQSSVYQTNSFRNPRYLCRAHLRVDSYYCTIPPKREVSLFNMDDNCTEVLLRDFAKDCGKVEKAYVCIHPETKRHMKMAYVKFATVKEAHNFYSMYHAQNLLATKCTPRIDPFLSILNEEYEVATNGQVLPILPDDLASIDPSVLRDLRANFLRDQNEKYELAMRNTYEDEGGMLSGVIMDTSDHYERDYTMDHDVGPSSMKMSPIPPPPIKEESPPPPPPPPVASVSNLAPVPSVQLPYYNNIQPSSSTMHMPEFRPTEPPPSYSREDPYRSTSRSSLSRHRNRSRSPSDGMDRSGRSSSRRTHRRPESRNGSKNANGDVVKYETYKMEKRKIKYEGGNKKYEQVHIKERTAVIRGKNQLENVSSESASGSSSVDTYPDFSDEERKKKKRPKSPNRSKKDSRAFGWDSTDESDEDTRRRRSGRSQNRSSERKFQTTSSSSTRRELSSTHTNSVPNLKSHETPPPPPPKGHPSVHLQTPYQHVQPQMIPATYYNLPPQHMAPPPITTSLPPFCDFSQPPPGFTPTFKPITNAPLPTPYQASNIPQPGLVQIAALSAAPEPFSSIPGPPPGPAPIQEDVGRAESPEKPSLSERFSGIFGPTQREEPAQVEVEYDYPLKHSESHDDRHSLEDMDVEVSSDGETVSNVEKIECMEEKKRQDLERIAIARTPIVKKCKKRMMDELSRKVAEDIRQQIMRQCFAALDEKLHLKAIADEEKRKKEREEKARQEAEKPSNHLIADMMTLYNNQSFASSSRGFYRKQKPIPKSHPKHQEHHHHAKASVSTPVHSSSTSRNSSVAPTPQRTVSTSSSSSSAATSARVSEDESDSDSTPGEVQRRKTSVLSNDKRRRRASFSSTSIQSSPERQRDVSSSSRTSSSSSTSSMKQEETADEKSRKRKLIMSSDESSTTGSTATSVVSSRQSSLEPQQEKTDGEPPKKKSQTDFISERVSKIEGEERPLPEPVETSGPIIGDSSYLPYKIVHWEKAGIIEMNLPANSIRAHEYHPFTTEHCYFGIDDPRQPKIQIFDHSPCKSEPGSEPLKITPAPWGPIDNVAETGPLIYMDVVTAPKTVQKKQKPRKQVFEKDPYEYYEPPPTKRPAPPPRFKKTFKPRSEEEKKKIIGDCEDLPDLEDQWYLRAALNEMQSEVKSADELPWKKMLTFKEMLRSEDPLLRLNPIRSKKGLPDAFYEDEELDGVIPVAAGCSRARPYEKMTMKQKRSLVRRPDNESHPTAIFSERDETAIRHQHLASKDMRLLQRRLLTSLGDANNDFFKINQLKFRKKMIKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYKFPIEDDKIDCLCGAKTCRGYLN

171.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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