Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

1269 amino acids

MELEQMVVKELGISMDDLRELIDRELEKIEFVKQRKAQLLEMEQLVKQKEAEVDHVDKLFDNATRAVDDCETLVKSLYDQIGMTYKESSSEDEGSSKPTEVIEIPDEDDDDVMSVGSGEAVSKIPKEKHLLREAMAAMKRSRQDVQSIVEAIQKKSDGPQTRFSSHPSSPTSSVGGSNQASASNDMSKDGDLVVGMRILGKKRTKTWHKGTLISIQCVGTGKKFKVKFDNKGKSLLSGNHIAYDYHPPPENLTVGSRVVAKYKDGNQVWLYAGIVAEPPSSKNKMRYLIFFDDGYASYVTHAELYPVCRPWSKSWEDIEDVSCRDFIQEYVNAYPNRPMVLLKSGQLIKTEWEGTWWKSKVEEVDGSLVKILFLDDKRCEWIYRGSTRLEPMFSMKTSNASTQEKQQAGQQRTRPNVGAIRSKGPVVQFTHDLTGNEPEHNPAAPPSPQSMPSPQLIDTDSDSQQAQSKKQVAKKSTSFRPGSAGSGQSSPIPTESVPQPPAAPRPFQSNQSVQPVQSIQPIQPIHNIQTIQTIQGIQTIQAIQPIQSIQTLQPIQTIQPLQTIQTLQGNRIVTSIQQFQIIRTENIPAESTYKAPKEKLFYLPHVCNYTCLSRIRPLSHRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKSPCGLSLRTMPEIERYLFETQCKMLFLEMFCLDPYVLVDRKFQPQKPFYYIPDITYGKEDVMLSCVNEIDRTPPPQVAYSKERIPGKGVFINTGADYLVGCDCTDGCRDKSKCACHQLTIQATACTPGAQSNPMAGYQHKRLEECLPTGVYECNKRCKCSANMCNNRLVQHGLQVRLQLFKTQNKGWGIRGLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAKSSSDSSGVDLKEDHEENSGSEDQEESNDSSDDNFGKNEDITTSSVWRSYATRRTTRGQKENGTSETASKDSRTRDETTDCKLPEETSKNKVASWLSSNTMADSVMDSDSRSSLKMGEALETDKPKESEEASKYPRFAEGNRAYGYNPTPTKKDGVRRPVTKTALHQIKRQSSSAQPTEEVLTLSSSSDSEVGSGTNGSKKPAAQATANDSDDIQTISSGSDEEEEKKNVAASAGPVKRQVAVKSTRGFALKSTHGITVKSNMASGEGGPGRRNTRQFFDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKKLLCCCGSTECRGRLL

141.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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