Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Plays a role in myogenesis by regulating the expression of target genes (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

855 amino acids

MKWLGESKNMVVNGRRNGNRLSAELRQNQPKLHSPGRENLRTSKNVPDRRSGRFGNVAFEAQSRYVPSSGMSAKELSENDDLATSLVLDPYLGFQTHKMNARFRPIKGRQEELKEVIENFKKKEHLEKTFKNLVAGDWSRHYFLNKTKMQEKHFKEHVFIYLRMFATSSGFEILPCNRYSSERNGAKIVATKEWKRNDKIELLVGCIAELSEAEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRATGAFKSRVGLNEPGPLINSKYGLRETDKRLNRLKKLGDSGKNSDSQSVSSNTDADTSQEKDMSNRKSNGMRKRSKSRTLRRRSMSRIPVSSSSTSSKLPHINNSRVPKRLRKPPKPFHSKLKIRCHRKKVEQKKASKKLEVSNLVLKEPKVVLYKNLAIKKDRESQGAVPVTETTGCLTRHAAREYKLNSLKGAHSHGESSSCTYITRSSLRTRFKSNDMSEAKLQHNSVDGYRSSHGTVLQVDKSEPLCQSTCKNELLQETPRQTIRFHRNNFNTSTRNSRQNRYIKQASKVEDSVSSVYDQSSKDHALPDLGNSHCDLGEGNALIQTSPDYKSFESSADEYPLVTSEITKTKKNNRTAKNKKSRRITRYDAQLILENSTGIPKLTLRRRHDSNSSKTNEKENEGMSSSKISIKLSKDHEKDNGLYVAKLNNGFNSGSGSTSTKLKIQLKRDEENRTAFPNENGMYCNDTLSLLETRMKVDGYDHYEEESVEESSTEEDEEEEDEYDDEFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA

97.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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