Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes (By similarity).

Belongs to the sulfotransferase 3 family.

356 amino acids

MGLLRIMMPPKLQLLAVLTFGVLMLFLENQIQNLEESREKLERAIARHEVREIEQRHSMDGSRQEIALDDDEDILIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNVSSWREMKPGFYHGHVSFLDFTKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALDQAKYNLVNEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRSGKKSHLRKTTEKKAPSKETTAKLQQSDIWKMENEFYEFALEQFQFVRAHAVREKDGELYVLAPNFFYEKIYPKSN

41.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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