Description
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/eng.
Family
Belongs to the TGF-beta family.
Sequence
MWRVGHLLLLMSIVFRITEEKSLGDAGSLEDSMFIQEQKLVEDDDLNKVESFLGFMKEDFLRKLNLSGVPQEHRKVQPPQFMIELYNRYASDKNSIPRSDVIRSFVVQDVIYSIRQGNKTQHRLLFNVSIPNHEEITSVQLRLFTLWHRHKPACDDLFTSINVYDVEYEQNAKILHLLDGRDVRESINTWEAFDVTGAVRIWHESRRGAGEIQVEVQHSCDSFDISLSLEDNSSAVVIVFSDDLGNRKEESMRKVKEMLVREQQQVGNQAPVSNRHRRRKRKAKNNYCRRTSLKVNFKDIGWDKWIVAPPEYDAYECKGVCYFPLTDDVSPSRHAVIQTLVNLSNPKKANMACCVPTKLDPIAVMYQEKGVITVRHLYEEMKVAKCGCR
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service