Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity).

Belongs to the peptidase S1 family. Granzyme subfamily.

258 amino acids

MNIPFPFSFPPAICLLLIPGVFPVSCEGIIGGNEVAPHTRRYMALIKGLKLCAGALIKENWVLTAAHCDLKGNPQVILGAHSTSHKEKLDQVFSIKKAIPYPCFDPQTFEGDLQLLQLEGKATMTKAVGILQLPRTEDDVKPHTKCHVAGWGSTKKDACQMSNALREANVTVIDRKICNDAQHYNFNPVIDLSMICAGGRKGEDDSCEGDSGSPLICDNVFRGVTSFGKCGNPQKPGIYILLTKKHLNWIKKTIAGAI

28.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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