Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes.

Belongs to the grh/CP2 family. Grainyhead subfamily.

594 amino acids

MSNELDYRPVMLLQNDINLKYSSPNDDEAWSKYLENPMTAATKAMMRANGDDDGVAALSLLYDYYRVPKEKRIITQGSTGRCDQVKRSCIEYDSDISTYDSTQLMRFLNDNNSSTHEYSETHKKNSYLSLDCLINPSKLPLSSGKLDNNAHDDFMATSCDVYEKNPLTTLFDPIHVPPPQQRWQPDSTFKEDTPEPLIFNDILRSQAESTCSEDYIPGEANRDFECTLESPKAIHIKSGESPMAYLNKGQFYPVNLRTAETRKCVHLTSNKVKSVVMVVFDNEKNPEEQLKRWKHWHSRQPTAKQRVIDVADYKENCNTVENIEEVAYNALSFVWNINEEAKIFIGINCLSTDFSSQKGVKGVPLNLQIDTYDFETGVKRLIHRAVCQIKIFCDKGAERKMRDEERKQFRRKGKSADQNNKDIKASVLPGYRGSDFTYLRPVTDMETHPVLFIPNIHYSNLQRCGVVLQSAADNSDRLSLKRSSQSFPESFEAPPSKQQTNEDPQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYELPEERICRVYKKCKRGILVNMDNNIIQHYSNHVAFLLDLTDVDGKIQVTLKEL

68.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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