The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Belongs to the GcvP family.

957 amino acids

MSQLPSLSQLRDPHAFLRRHLGPDAAEQQAMLDSLGLGSRVELIEQTVPPGIRLNRELDLPPALDEQAALARLRGYAEQNQVWTSLIGMGYHGTLTPTVILRNVLENPGWYTAYTPYQPEIAQGRLEALLNFQQLTIDLTGLELANASLLDEATAAAEAMALAKRVAKSKSNLFFVDENCHPQTISVVQTRAEGFGFELIVDAVDNLKQHQVFGALLQYPDTHGEIRDLRPLIDHLHAQQALACVAADLLSLLLLTPPGELGADVVFGSSQRFGVPMGYGGPHAAVFASREEYKRAIPGRIIGVSKDARGNVALRMALQTREQHIRREKANSNICTAQVLLANIASFYAVYHGPEGLKRIAQRVHRLTCILAAGLERHGIQRLNQHFFDTLTLDVGGAQTAIIESAQAAQINLRILGRGQLGLSLDEACDENTVARLFDVLLGADHGLSIDDLDAETLASGIPEMLQRSTSYLRHPVFNAHHSETEMLRYLKQLENKDLALNQSMIPLGSCTMKLNATSEMIPITWPQFANLHPFVPREQAVGYTLMIEELERWLCAITGFDAICMQPNSGAQGEYAGLLAIRKYHESRQQGGRDICLIPSSAHGTNPASAQMAGMRVVIVECDDAGNVDLEDLKAKASEAGAKLSCLMATYPSTHGVYEEGISEICEVIHKHGGQVYMDGANLNAQVGLARPADIGADVSHMNLHKTFCIPHGGGGPGMGPIGVRAHLAPFVANHPVVPIDGPQPQNGAVSAAPWGSASILPISWMYIAMMGPQLADASEVAILAANYLAQHLSGAFPVLYTGRNERVAHECILDLRPLKAATGISEEDVAKRLMDYGFHAPTMSFPVPGTLMVEPTESESKAELDRFIGAMLSIRAEITEVQNGNWPAEDNPLKRAPHTMADITGVWERPYSIEQGITPDAHTKAHKYWPAVNRVDNVYGDRNLFCACVPVDDYR

104.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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