Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation (By similarity).

Belongs to the glutaminyl-peptide cyclotransferase family.

368 amino acids

MARERRDSKAATFFCLAWALCLALPGYPQHVSGREDRADWTQEKYSHRPTILNATCILQVTSQTNVSRMWQNDLHPILIERYPGSPGSYAVRQHIKHRLQGLQAGWLVEEDTFQSHTPYGYRTFSNIISTLNPLAKRHLVIACHYDSKYFPPQLDGKVFVGATDSAVPCAMMLELARSLDRPLSFLKQSSLPPKADLSLKLIFFDGEEAFVRWSPSDSLYGSRSLAQKMASTPHPPGARNTYQIRGIDLFVLLDLIGARNPVFPVYFLNTARWFGRLEAIERNLNDLGLLNNYSSERQYFRSNLRRHPVEDDHIPFLRRGVPILHLIPSPFPRVWHTMEDNEENLDKPTIDNLSKILQVFVLEYLNLG

42.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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