Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.

Belongs to the nuclear hormone receptor family. NR3 subfamily.

771 amino acids

MDLKESVTSSKEVPSSVLGSERRNVIDFYKTVRGGATVKVSASSPSLAAAAQSDSKQRRLLVDFPKGSGSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLPSGETDFRLLEESIANLSRSTSVPENPKNSASAVSGTPTEEFPKTQSDLSSEQENLKSQAGTNGGNVKFPPDQSTFDILKDLEFSSGSPGKERSESPWRPDLLMDESCLLSPLAGEDDPFLLEGNSNEDCKPLILPDTKPKIKDNGDGILSSSNSVPQPQVKIGKEDFIELCTPGVIKQEKLGPVYCQASFSGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGEDNLTSLGTVNFPGRSVFSNGYSSPGLRPDVSSPPSSSSTTTGPPPKLCLVCSDELSGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRENCPACRYRKCLQAGMNLQARKTKKKIKGIQQATTGVSQNTSENPNKTIVPATLPQLTPTLVSLLEVIEPEVIHSGYDSTSPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFKNLHLDDQMTLLQYSWMFLMAFALGWRSYKQSNGSLLCFAPDLIINEQRMSLPWMYDQCRYMLYVSSELKRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSLHEIVGNLLNICFKTFLDKTMNIEFPEMLAEIITNQLPKYSNGDIKKLLFHQK

84.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make NR3C1 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here