Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

single

1214 amino acids

NKGKTFTSKYVIMTSNTETPVKPTSRRAGAFYRRVMIVDVTNNAVEKWKSDNPGKAVPKWCFNKDFSHLSLSLRGTEAYCKEYVLDPTGRNHQSRRAPPPQQVTLEQLAQKMVVQHTTNTSEFVTQAGDVPVFGFVCQNNEIDTVYNLLAAVKARYGANFNLYKGMVRTAHENSGCGAHVHVISREDNFRGKVFTVSRSRLESVPHLEGDSFRRSLGVVMSDKDVTTMFYYIKGKVINDQVNLTELPANQHVVTVHTVYDMAWALRRHLKWSGQWQLIKAAFEIMCYPDAAACALRNWMDSTDFSEEHVVTQFIAPGGTIILESCHGARMWATGKRLIRAGGITEAGGPQGGVRFAGLGARNVPWSEILREFMTLISHIWSQIKGATVVLTALTFYLKRFRPRIEAKGKNKNKGARKNTGVALTDDEYDEWRQYRTEKNLDLTVEDFLQLRHRAAMGADDSDAVKFRCWYSERQRNYHDLEDVTIIGRGGVKRELIRKGPLRPRGNDYYDEPDDWYSEGVIDGVAHKNAIVSVDDVDGMHKGYAIHIGHGVYISLKHVVSGNARILSEEPKNLTFTGELATFRLNNILPTAVPVGTSKPIKDPWGNPVSTDWQFKNYNTTSGNIYGACGSSCSLTRQGDCGLPYVDDHGVVVGLHAGSGGDKCPSRKLIVPYAKVDMRVRDTCTKQCYKDNSPTISYKGLLVKETGEPRTIMKGTRLHVSPAHTDDYEECTHQPASLGAGDPRCPISLTGIMVNNLQPYTEASPGPDTATLNRVSKMLTSHMEGYVQKSQTEEGYGSAFYMLNHDTSCGPYIGGRKKDHVKDGVLDKNLLDLLSSKWNRAKLGLALPHEYALGLKDELRPKDKVAVGKRRLIWGCDVGVSTVCRAAFKRVSESIMANHALGFIQVGINMDGPAVEDLFKRLERPKHDRYCVDYSKWDSTQPPKVTSQSIDILRHFTDKSPIVDSACATLKSNPIGIFNGVAFKVAGGLPSGMPLTSIINSLNHCLMVGSAVVKALEDSGVQVSWNIFDSMDLFTYGDDGVYIVPPLISSVMPNVFANLKQFGLKPTRTDKSDAEITPIPADEPVEFLKRTIVRTENGIRALLDRSSIIRQFYYIKAENTENWTIPPKKIDTPSRGQQLYNACLYASQHGEEFYTNKIIPLVQRAIEFEGLHIEVPEFHHAVAAYNGYFNGTEGQPNQIAFASGGLGLSSEVFEN

135.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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