Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1, eIF4G2 and PABP1 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs.

1763 amino acids

MSQTLSFVLKTHSVRKDFVHSVKRTLQRRRDLQYLYNKLSRPIRAEACPSCASYDVCPNCTSGSIPDDGSSKGQIPSWEDVTKTSTYSLLLSEDTSDELHPDDLVNVAAHIRKALSTQSHPANVDMCKEQLTSLLVMAEAMLPQRSRSTLPLHQKYVAARLEWREKFFSKPLDFLLEKIGTSRDILQITAVWKIIIEKACYCKSYGEHWFEAAKQKLREIKSYEHNTLKPLIGAFIDGLRLMTIDNPNPMGFLPKLIGLIKPLNLAMIIDNHENTLSGWVITLTAIMELYNITECTIDVITSIITGFYDKIGKATKFYSQIKALFTGFRSEDVANSFWYMAAAILCYLITGLIPNNGRLSKIKACLAGATTLVSGIVATQKLAAMFATWNSESIVNELSARTVAISELNNPTTTSDTDSVERLLELAKILHEEIKIHTLNPIMQSYNPILRNLMSTLDGVITSCNKRKAIAKKRPVPVCYILTGPPGCGKTTAALALAKKLSDQEPSVINLDVDHHDTYTGNEVCIVDEFDSSDKVDYANFVIGMVNSAPMVLNCDMLENKGKLFTSKYIIMTSNSETPVKPSSRRAGAFYRRVTIIDVANPLAESHKRARPGTSVPRSCYKKNFSHLSLAKRGAECWCKEYVLDPKGLQHQSIKAPPPTFLNIDSLAQTMKQDFTLKNMAFEAENGHSEHRYGFVCQQGEVETVRRLLNAVRTRLNATFTVCVGSEASSSIGCTAHVLTPDEPFNGKKYVVSRCNEASLSALEGNCVQSALGVCMSTKDLTHLCHFIRGKIVNDSVRLDELPANQHVVTVNSVFDLAWALRRHLTLAGQFQAIRAAYDVLTAPDKVPAMLRHWMDETSFSDEHVVTQFVTPGGIVILESCGGARIWALGHNVIRAGGVTATPTGGCIRFMGLSAQTMPWSEIFRELFSLLGRIWSSIKVSTLVLTALGMYASRFRPKSEAKGKTKSKVGPYRGRGVALTDDEYDEWREHNATRKLDLSVEDFLMLRHRAALGADDADAVKFRSWWNSRSRLADDYEDVTVIGKGGVKHEKIRTNTLRAVDRGYDVSFAEESGPGTKFHKNAIGSVTDVCGEHKGYCVHMGHGVYATVAHVAKGDSFFLGERIFDLKTNGEFCCFRSTKILPSAAPFFPGKPTRDPWGSPVATEWKPKPYTTTSGKIVGCFATTSTETHPGDCGLPYIDDNGRVTGLHTGSGGPKTPSAKLVVPYVHIDMKTKSVTAQKYDVTKPDISYKGLICKQLDEIRIIPKGTRLHVSPAHTEDFEECSHQPASLGSGDPRCPKSLTAIVVDSLKPYCDKVEGPPHDILHRVQKMLIDHLSGFVPVNISSETSMLSAFHKLNHDTSCGPYLGGRKKDHMTNGEPDKPLLDLLSAKWKLATQGIALPHEYTIGLKDELRPVEKVAEGKRRMIWGCDVGVATVCAAAFKGVSDAITANHQYGPVQVGINMDSPSVEALHQRIKSAAKVYAVDYSKWDSTQSPRVSAASIDILRYFSDRSPIVDSAANTLKSPPIAIFNGVAVKVSSGLPSGMPLTSVINSLNHCLYVGCAILQSLEARGVPVTWNLFSTFDMMTYGDDGVYMFPMMFASVSDQIFANLSAYGLKPTRVDKSVGSIEPIDPESVVFLKRTITRTPQGIRGLLDRSSIIRQFYYIKGENSDDWKTPPKSIDPTSRGQQLWNACLYASQHGVEFYNKIYKLAQKAVEYEELHLEPPTYHSALEHYNNQFNGVEARSDQIDSSGMTALHCDVFEV

194.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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