Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.

Belongs to the gamma-glutamyl phosphate reductase family.

428 amino acids

MLKLHEKSGDDTVALMADIGRRARAAARPLAIAPTAAKNAALLAMADAIVARQQDILDANAIDVSNGEEAGLSASFMDRLKLTPARIRAMADGIREIAELKDPVGDVIAAWERPNGLRIERVRTPLGVVGVIYESRPNVTADAGALCLKAGNPVILRGGSDSLNSSAAIHACLVEGLKAAGLPEDAIQLVPTTDRAAVGEMLKGLGGALDVIIPRGGKSLVGRVQSEARVPVFAHLEGICHLYIDRSADLDMAVKIAVNAKMRRTGVCGAAETLLVDRAVASTHLVPILDALRAAGCEIHADQEVLKVFFDAKPATDADWVTEYLDAIIAVKLVDGIGGAIEHIETFSSHHTEAIIAEDPKAVERFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVRGSGQVRP

45.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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