Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

Belongs to the class II fructose-bisphosphate aldolase family.

359 amino acids

MARITLRQLLDHAAERSYGVPAFNINNMEQGLAIMEAARACDAPVILQVSRGARSYANDIMLAKMMEALEVMYPDIPLCIHQDHGNNVATCLTAIQHGFTSVMMDGSLKEDAKTPADYAYNAMITTEVSRLAHMVGASVEGELGCLGSLETGHGEAEDGHGFEGALDRSQLLTDPDEAARFVAETGVDALAVAIGTSHGAYKFTRKPTGEVLAMDVIEKIHERLPDTHIVMHGSSSVPQEWQDVFNAHGGEMRETYGVPVEEIVRGIRFGVRKVNIDTDLRLAAAAAFRRVADTSRTEFDPRKFLKPAMDAMSAVCKARFEAFGTAGNASRIKVVPMAEMARRYASGSLKPQAKRAEAA

38.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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