Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Belongs to the FBPase class 1 family.

338 amino acids

MTDQAAFDTNIVTVTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGTTNVTGDQVKKLDVLSNDLVVNVLKSSFATCVLVSEEDEHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYKKISKDDPSEKDALQPGRNLVAAGYALYGSATMLVLAMANGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSLNEGYAKDFDPALTEYVQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPSGKLRLLYECNPMAYVIEKAGGMATTGKETVLDIVPTDIHQKSPIILGSPEDVTEFLEIYKKHAAK

36.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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