Description
Transcriptional repressor that down-regulates bmp4 signaling in both mesoderm and ectoderm. Regulates mesoderm patterning by repressing ventral mesoderm genes and promoting the expression of dorsolateral genes. Can also neuralize ectodermal cells directly. Inhibits neural crest migration. The transcription factors foxd1 and foxg1 mutually repress each other to pattern the forebrain (By similarity).
Species
Xenopus tropicalis
Sequence
MTLSSDMSDVLAEETDIDVVGEDDEPRAEEEEDEDLHGDLLPTSPQSSATKDPYKGTGGGGGRSALVKPPYSYIALITMAILQSPKKRLTLSEICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQQAPELVLREPGHFLPASAYSYGPYSCAYGIQLQPFHPHSALIAFQQQQQQARQQPPSLPPMAAPALMPPAAQDLSRTCTFYPHQLSPAALPPSLQSKSSSALARSTFSIESIIGGDLNPGQCNSPKAAGVPVISRALVTFSSSQAAAALGGTLQPGTVLTNH
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
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Protein synthesis service