Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).

378 amino acids

MASKPEKRVASSVFITLVPPRRDEAVVEEVRRAACEAWPGRPWESAPTKAPGAGSVGKLRSWMPPGRAAAPGPAVPPQLSNGGCSLPPPPLDVDDALPDLDLLPPPPPPPAADLPPPDEEPHSAMGASLISDLEQLHLPPPPPPPQALVEGPPLQPRPSHLKPAEEELPPPPEEPVSFPEREASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRVCRRQLAGQSFYQKDGRPLCEPCYQDTLEKCGKCGEVVREHIIRALGQAFHPSCFTCVTCARRIGDESFALDSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRVLLSVEPTDQGCYPLNNRLFCKPCHVKRSAAGCC

41.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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