Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).

Belongs to the kindlin family.

665 amino acids

MAGMKTATGDYIDSSWELRVFIGEEDPEAESLTLRVTGESHIGGVLLKIVEEIKRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQAMVAICRLLSIRHPEEMSLLRAPEKEKKKKKEKEPEEEVYDLTKVVLVGGVAPASFRGMPAHFSDSAQTEACYHMLSRPQPPPDPLLLQRLPRPSSLLDKTQLHSRWLDSSRCLMQQGIKAGDTLWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLLLEEIDCTEEEMMVFAALQYHINKLSQSGEVDEPAGTDSGLDDLDLALSNLEVKLEGSAPTDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQHWVVFKETTLSYYKSQDEAPGEPIQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYARWMAGCRLASKGRTMADSSYSSEVQAILAFLSLQRTGGGGGGSGNHPQGPDASAEGLNPYGLVAPRFQRKFKAKQLTPRILEAHQNVAQLSLSEAQLRFIQAWQSLPDFGISYVVVRFKGSRKDEILGIANNRLIRIDLSVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGHEAF

75.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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