Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).

357 amino acids

MPFLGQDWRSPGWSWMKTEDGWKRCDAWSQELEGENSQCDIGHGIILNSEDEEIFSNEEHEFASKKRKKDHFRNDTNTQCFYRENWIYVHKESTRERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVRLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLGDHQNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETVLRWQQQLQNLQMTEVDSGLTLSDLPVHMLSNILYRFSDGWDIVTLGQVTPTLSALSEDRQLWKKLCQYHFGEKQFCRHLILSEKGHVEWKLMYFALQKHYPTKEQYGDTLHFCRHCSILFWKDSGHPCTAADPDSCFTPVSPQHFIDLFKY

41.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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