Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions.

Belongs to the fatty acid desaturase type 1 family.

445 amino acids

MGGGGQLTEPGEQGSGRAGGVYTWEEVQSHSSRNDQWLVIDRKVYNITQWAKRHPGGIRVISHCCGEDATDAFAAFHPDQRYVRKFMKPLLLGELTPSEPSQDHDKNAALMEDFRDLRKRLESQGLFRTSPLFFILYLGHILLLEALSVALLWNFGNGWIISLLLSVLLATSQAQAGWLQHDFGHLSVFKNSTWDHLMHKFIIGHLKGASANWWNHRHFQHHAKPNIVSKDPDVNMLNILVLGNILPVEYGIKKVKHMPYNHQHRYFFLVGPPLLLPLYFNLHVIQTMYLQRDWVDFAWFLSYYARFFMFYSPYYGILGSLVLITFVRFLESHWFVWVTQMNHIPMDIDHDKHDDWLSMQLKATCNIEHSQFNDWFSGHLNFQIEHHLFPMMPRHNYSRASPQVRELCEKYGIQYQVKGLWESWCDIVRSLKKSGELWLDAYLHK

52.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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