Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high (PubMed:21562563). Facilitates axon regeneration after injury by degradating inhibitory compounds such as AEA (PubMed:23072806).

Belongs to the amidase family.

572 amino acids

MIFYLVLLVLGAIAFYVHFSNNRKKLIERLEIVAQRRRDDLSKNVEQARKAADKLDTQRRDWIGSLDFEQLRDELQRGHVTCVEAIRAYFHKAILAHEKTNAVTCFILDAERQAEELDEQAKLPYYVKPPLFGVPLSLKECLKVKGYDTTRGFVQDAYHPATEDSIQVEHYKKLGLIPFCQTNVPQSLLSYNCSNPLFGTTTNPYDSTRTCGGSSGGEGALIGAGGSLIGIGTDVGGSVRIPCHFTGTAGIKPSKMRFAHRGGGASVPGKPLIDANDGPMAKDVKTNVEFLRNVWGDIDFQSDRDPYCPPVHWNESVYSSEKKLRVGYYIDDGWFTPTPALQRAVLESKKHLEAAGHTVIPFYPPRLPSVMQLYFRAVCLDGGQYVLNKLLKDIIEPTIRFQVTLWMVPVWIQRILSYPVSLVFPRMGMLMQSLTRDTFELREAYADIEAYREEFVGLMMKDNLDVILCPASIMPAPQHDIPSKVVSGVSYTCLYNLLDFGAGVVPVTAVSKSDEEKLINEYPETDKWYQITKKATLGAVGMPIGVQVAAPPYREEAVLRTMREIEIAVTGK

64 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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