Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and prevent repolymerization.

Belongs to the Mical family.

1214 amino acids

MVNPLDSVNPSHALFEGFVQAQTCKETQQNFTELCRHLQVDPKDYKHFYSKLKDRLNYWKAKDLWQKIDKRAAHPDYDQGKACHQNKCLVLGAGPCGLRTAIELALLGAQVVVLEKRSSFTRNNVLHLWPFTIKDLLNLGAKKFYGRFCSGSIHHISIRQLQLILLKVALFLGVEVHTGVAFEGLNEPSGSAGWRANVSPKSHPVADFQFDVFISAGGGKYVPDGFKIKELRGKLAIGITANFVNRHTKQEAQVQEISGVARIYNQQFFQALQSEIGVDLENIVYYKDDTHYFVMTAKKASLLKKGVIKQDFSDADKLLAPSNVNQEALQDYAFEACDFSTEHLLPNLEFAKNHKGQADVAMFDFTCMQRAESASLVKERNGKRLLIGLVGDSLVEPFWPLGTGIARGFLGAFDAAWMVRSWGKGVQPMEVLAERESVYQLLSQTTPENTSKNYMAYSIDPSTRYPNINLSSIKPRQVKRLYEAEEQESKPNKLKKPDIKAKPRKDSMKRLEELLSWCQKNTVGYEHVKVKDLSESWRSGLALCALIHSFRPELVDMSALDEYNIIKNNKLAFDLMEKEFGITPIMRPGDMMTCGKIDQLSMVVYLTQIRNALTEKDTPAAQSNTLSLSRKRSAVAFLNTLKRNSLQRHKDRLASVKGPRQQNMKEKEEKKDVKEESLSSETSACEPCYFCKKHLYVVERESAEGKFFHRSCFNCFQCGSTLRQGGYSFHSDNGRFYCELHSLAEEEEGDEGHGGAQNHTENGSKEDKNGETTAASSPPAHLSIKRKGSYKISVDPDFDESTEFPAPDQDEPPDLEESHQPPKPSELSAENTNMENQQHNINPVPAPRGSRAPLPKPRTVHNVVHEPCNIPEEAEQIPEEPKPKPSLRKLQQSEEEKVDLLSQDSDSETRGSSSAASTSSSSKQHEEEGYWSGGTTWGKSHREQRNRPCIRRKSEPPLPLTGHSQHGKMRSKFSPWNLSSPRLQQRFSVHRVPAGQSQPDQYVSEDDNEDDEDEDEEDLQAEHYLDCEGADFEFSDSEKRNLKRMKTLERKAKMTEIQRFHKAQSIQRRLEEIEVTFKELEEKGVELERALRGETGTGDPEIIDQWIELVQEKNNLLSEESDLMVASRQLELEDKQSMLEMELRRYMEMDDSEKSPEQQKHEAEILQEMLDVVDMRDSLVAFLEEKRLKEVNDQFNSSLDAKRRSTTASQVHWE

138 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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