Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).

209 amino acids

MDPFLVLLHSVSAGLSSSDLTQLKFLCQNHISKRKLELAQSGLDLFTVLLQQNELNAEHTALLRELLCSLRRKDLLLRLDDFERGAAGGAAPEDRDLRAAMEIICDNVGKDWRRLARHLGVSDVKIEAIEEKYPRNLAEQVRELLRVWKNSTRENAAVSCLVGALRGCQLNVVADLIEEDQRARALQSGSANPGSFTAWDSGSAAPGAS

23 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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