PaxA is associated with abortion cases in swine and septicemia in young piglets. Shows cohemolytic activity with the sphingomyelinase of S.aureus but is devoid of direct hemolytic activity.

Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.

1049 amino acids

MSTWSSMLADLRKQAEIAKQQAKKGIDVTKNGLQYGVSQVKLQALAAGKSIQKYGNKLVLVIPKDYDVNTGNGFFDLAKAAEELGIQVKYIDRNDLEIAHKSLGVTDQFLGLTERGLTLFAPQLDKFLQQHSKISNVVGSSTGDTVNKLAKSQAIISGVQSVLGSVLAGINLNEAIISGGSELELAKAGVDLASELVGNIAKGTATIEAFSEQIQNFGKLVQNAKGLGGVGQQLQHISGSALSKTGLGLDIISSLLSGVTASFTLADKNASTSTKVAAGFELSNQVIGGITKAVSSYILAQRLAAGLSTTGPAAALIASSISLAISPLSFLRVADNFNRSKDIREFAERFKKLGYEGDKLLSDFYHEAGTIDASITTISTALSAIAAGTAAASAGALVGAPITLLVTGITGLISGILEFSKQPMLEHVASKLGTKIEEWERKYGKNYFENGYDARHKAFLEDSLSLLSSFNKQYETERAVLITQQRWDEYIGELAGVTGKGDKISSGKAYVDYFEEGKLLAKKPDDFNRVILDPKKGKIDISNSQTSTLLKFVTPLLTPGTESRKRTQTGKYEYVTKLDVNGINQWEVNGVKEKGAVYDFTNLIQHVHISSSVARGEEYREVRLVSRLGKGNDKVFLASGSAEIHAGDGHDVVYYDKTDTGLLMVDGTQATKQGDYTVTRELSGATQILREVVKNQKSSVGSRQETVEYRDNELAQSGNSNLKAKDNLYSVEEIIGSNHRDEFKGSKFRDIFHGADGDDLLNGNDGDDILYGDKGNDELRGDNGNDQLYGGEGNDKLFGGNGNNYLSGGDGDDELQVLGNGFNVLRGGKGNDKLYGGAGSDFLDGGEGDDYLAGGEGNDFYVYRSTSGNHTIYDQGKSSDSDTLYLSDLTFDRLLVEKVDNNLVFKPSDHNSNRGSLTIKDWFKTGHGYNHKLEQIVDKNGRKLTSDNLETHFNGTPKTNLLGYTAENQNESNLSSLKTELGKIISSAGNFGLAKQGNNNHSAALNNDVDKLISSASSFATAQMGGSGIGLLPSNNANSTILSGLARTA

112.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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