Single strand DNA specific 5'exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).

Belongs to the EXO5 family.

554 amino acids

MLRCRSSINILQLHSRFHTHEIIISSKESEARTRITDEERLVIKRFPIFKNDSSYILPSSNKLTKVKKEHIALKIHKIKKLFGEDPNNVGYLNYHLPKSYPVPFEINNRAYDNSDGNGENEKVRNRLSVTKLLTKRWCELREAYDIYSETPLFEHKQIIEGKLVHQKLEEDIHPVTEDLESFVEDFEVPIPTDNFHNHVDDLFSCSMRLLSLFRCGEAREVRCHAFLDSRTGTFIDGLPKDGKDVLVSGIIDHLSLRRKIRVFTSSGFTEFNGLNDEVFENGNNFQSIIEWLNANIDFLKSEYQINVSDVKTRMFRSVVSQKSVLKYSKYQVMYYRYFLELLGLHPDVTYGQLLNSSLSRGFNIDQRIDPAKVIYFMASDEVIVDDMRKLRDGDDIGFPPFDSDFTGSSPTEEEYDMSILSDQITDPNVLERYGEFLVPWKRPVTLKYFAARLAQMYNCISPLLSKHLTLEYYYKGDNFKNINFDFNEDEIRNGAFDSSMFWFGKRDIEPIEPTSENLITYCKYCDYVNVCSWRQKATQQKKELGPRLLKLNQN

64.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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