5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).

Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.

732 amino acids

MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTHDMALRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSGLLVEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYETDERYCSNAGTLLEDSEQALHLALGNLNPFSMKRLDSWTPEKAWPTPKNVKRSKHKSIWQTNFQSENTHTPKKENPCALFFKKVDFVGKTLNEEIEANQRLEQAKQTEAELFNMYSFKAKRRRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGEEANQRSPVVCENASLLRLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQVQIRSRFFATQDEQTRLQREHLRDTENDDMDEQKLSSHSGHKKLRLVCKDIPGKNPIRQRCSSQISDGETDTDTTASSLLESQDKGVPSPLESQEDLNNSQPQIPTEGNTNSTTIRIKSLDLLLENSPEPTQESDRNNNDAIILLSDDSCSSDQRASSTSSSSQQRQNFLPTSKRRVGLSKPSTAKKGTPKSRTNGKLGAVSQNQTKLSMFGFQTKPVLK

83.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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