Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps (PubMed:10744754, PubMed:9553113). Probably by regulating mRNA translation in somatic cells, negatively regulates lifespan independently of daf-2/insulin and let-363/TOR pathways (PubMed:17277769). Negatively regulates resistance to oxidative stress (PubMed:17277769). May play a role in embryonic development (PubMed:17277769).

Belongs to the eukaryotic initiation factor 4E family.

228 amino acids

MSEEPVAAPGTISHPVYKLKRNWTWWYLNDERNKSWEERLKNVKTFSSVGEFWALHDSIKPPSGLNPPSDYNVFRDGIEPMWEVPQNQNGGRWLITIEKGRTPEIMDTIWTEILMAMIGEQFSDDIESLCGIVCNVRGKGSKISVWTTNSADDGANLRIGGVLKQVLNNASMIHQRPLYDVLRYEDHESCQKKTSSGVKAKHAIYAVEPREEKAPVPVSTETPATPAT

25.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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