mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

Belongs to the eIF-3 subunit D family.

591 amino acids

MTNPTPGLSGLVDLIDSLPDLGATWGPAITTETTLNGVPYAPYSKGDKLGRMADWTADSKDGRDGRGGRQQYNRNFRDQQIYGAGSTSIFAPPVAEDESSFSVVSNVKDTGKTRFGRGAVFTRGRGQRGGAGAQAGRGGGRQTFQRTGRGGQQYGGGYDGGRGGRQNTGARGRRFGWKDYDKPQRNRDASINIKGDWKLIEEIDYNRLSKLNLETDEGEDVDDYGFLYAYDRSYDKPVVKNAERRLAAIDRAAYNVTTSSDPVIQELAEKDEATIFATDNILSMLMCAPRSVAPWDIVISRQGNKIFFDKRDNAALDLVTVNENAADAPLDASEGSKDGINQPHALAEEATFINHNFANQVVVENESEKVNMAHENPFYNASEENVPPASKAYKYRRFDLSTSEEESTFLVVRTEIDAVQKNATDGKNQLVTVHALNEWDSKAQGAGGALDWRTKLASQRGAVVATEMKNNSCKLARWTVQSILAKADVMKLGFVSRVNPKVNDKHVILGVVGWKPKDFANQMNLQLSNGWGIVRTIADMCLKSESEDAKFVLVKDPNKNILRLYEVPAGSLDEEAEELDQVEEDGEEAEE

65 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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