RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

Belongs to the eIF-3 subunit B family.

719 amino acids

MADVTSMGEITAIAARIGVDLSQIDLDSIHLPPGEDCGIPSDDDDLMEEDPLEFDAGFGNILVVDNLPVVPKEKFEKLEGVVRKIYSQLGVIKEDGLWMPVDPETHKTLGYCFIEYNTPQEAELSKEKTHGYKLDRSHIFAVNMFDDIERFLKVPDEWAPPEIKPYVPGENLQQWLTDEKARDQFVIRAGNDTEVLWNDARQLKPELVYKRSFWTESFVQWSPLGTYLATVHRQGGAIWGGATTSNRLMRYAHPQVKLIDFSLAERYLVTYSSHEPSNPRDSHAVVLNISDVRTGKVMRDFQGSADEFAVGGTGGVTGVSWPVFRWSGGKQDKYFARIGKNVISVYETETFSLIDKKSIKVENVMDFSWSPADPILALFVPECGNQPARVSLVQIPSKEELRQKNLFSVSDCKMYWQSNGDYLAVKVDRYTKTKKSTYTGFELFRIKERDIPIEVLELDNTNDKIPAFGWGPEGSPICCYPSVTTPRPDIRFYSVPVWALTPGLVSKLTTLKGKQANALYWSPGGRFLILTGLKGFNGQLEFFDVDELETMASAEHFMATDVEWDPTGRYVATSVTSVHEMENGFNIWSFNGKLLYRILKDHFFQYLWRPRPPSFLSKEKEEEIAKNLKRYSKKYEAEDQDVSLQLSEQDREKRKKLKEEWEAWINEWKRLHEEEKMERQKLRDGEASDEEEEYEAKEVEVEEIINVTEEIIPFEESQQ

82.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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