Description
S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes the last step in the erythromycin biosynthesis pathway. Methylates the position 3 of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. Can also methylate the precursor erythromycin D, forming erythromycin B.
Family
Belongs to the methyltransferase superfamily.
Species
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Sequence
MSVKQKSALQDLVDFAKWHVWTRVRPSSRARLAYELFADDHEATTEGAYINLGYWKPGCAGLEEANQELANQLAEAAGISEGDEVLDVGFGLGAQDFFWLETRKPARIVGVDLTPSHVRIASERAERENVQDRLQFKEGSATDLPFGAETFDRVTSLESALHYEPRTDFFKGAFEVLKPGGVLAIGDIIPLDLREPGSDGPPKLAPQRSGSLSGGIPVENWVPRETYAKQLREAGFVDVEVKSVRDNVMEPWLDYWLRKLQDESFKKSVSRLFYSQVKRSLTSDSGMKGELPALDFVIASARKPGA
Simulated SDS-PAGE
![Western blot of eryG recombinant protein](/recombinant/eryG-1.png)
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service