The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).

491 amino acids

MGKFCLYFCLIYILFSASSGNPSRCTLFIGASSYHSDPCGSDHPRCTWRLDLFSLTRDQSLSPPCPDLVTYSQYHRPYSLYVFPHWITKPNRRGLGYYSASYSDPCAIQCPYLGCQSWTCPYTGPVSSPHWKYSSDLNFTQEVSSISLHLHFSKCGSSFSFLLDAPGYDPVWFLSSQATQAPPTPAPLIQDSDLQHILEPSIPWSSKILNLILLTLKSSNYSCMVCVDRSSLSSWHVLYDPLKAPNPPDPKAQSILRPSLAIPASNVTPPFPWTHCYRPLLQAISSEHCNNSVVLPPFSLSPLPNVSRPRKRRAVPIAIWLVSALAAGTGIAGGVTGSLSLASSKSLLREVDQDIDHLTQAIVKNHDNILRVAQYAAQNRRGLDLLFWEQGGLCKAIQEQCCFLNISNTHVSVLQERPPLEKRVITGWGLNWDLGLSQWAREALQTGITLLALFLLLIVVGPCVIRQLQALPSRLQHRSQPYSLLNYETNL

54.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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