Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).

Belongs to the enhancer of polycomb family.

1016 amino acids

MAIHPSKGTGGSKQSNSGARFRQRKISVKQPLTIYKQSDLPTLNASNDLEPSQIHHLNSNANQQQRDIHAIETGVDKNEEDEVHLQQVINAAQKVLLGSQNEDGDKKKDDSDKKTDASVYIPTPDASRIWTDASKYYNDKSFREPETYIKFSATVEDTVGVEFNMDEIDEEFLKNKLWKNYPKVKSPKVKSEKLDDTNKENDNARKCSEVEFEIICDKLEKIIEEKQPFLSMDPSNILSFKELSAYIIEEFNNSNKDKPYVQLGSNLKYISTTALKEKLSKELSFEPFVTLFDKSLLDQTSTNIVRPIPKLLELFGEPVYEHWKYRKIERKGKQIHPALKFEDPSANEKDNDNDPYICFRRREFRQARKTRRADTLGAERIRLLQKSMHRARDLVMSVCRRELIKLENWETDHAIFKLRSDAKNLKRVVGVKGDDFLFYPHKRKKIIKVKEEDEDKESSKIKRDKRSRFDSSREGSATSMPGSATIGTNAINKDRLANGQVHHTQEASSSSQPYVKLPPSKIPDMGLVTVSLVLKEKNETIKRAVLEKLRKRKEQDKDFINVTDDPYQPFFNIATNTKFKNNELKHIPYSSIAATSFHEINTTNYISEKLKNLLEEGKKPLPGTKTFRGSNGELIPSKPFPHLSALIQDRIDNSQFNSVSYIAQLLSNIENNNFSAYNNGYGQQQQHQHQETNRDKTKLSDPIFRLRKRVGRFNRNFVDRRGLMKRPNDVIDDFLKFDDEGVNDDCDQMDVDSESISKNNVPNVYDSRVDEIKRLDSRWQFDNDLTEYDKGLQSPFSLDPSRLNCISDDTQSIRFGSMLLSKSYDLLRDSVHQRQQALVQQARMRTLQQQQRNNKQQAAGQSSGSSSASLGSNTNSNSSISGQADQGQTNLTNSGITRQGGANVNGSQTSTTNNTRSSVSGGSMNPKLPTQSSQRSNTNSPLLASQPQGYSQQQKFNKIPPTSQSQSQSPTHAAGQLQTSKMYNKHGSNITPSNLKGPKFTPANNNQIGGSLPNRK

115.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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