Transcription factor NRF1: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses. Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response. Activates or represses expression of target genes, depending on the context (By similarity). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (By similarity).

Belongs to the bZIP family. CNC subfamily.

772 amino acids

MLSLKKYFTEGLIQFTILLSLIGVRVDVDTYLNSQLPPLREIILGQSSAYTQTQFHNLRNTLDGYGIHPKSVDLDYYFTARRLLNQVRALDRFQVPTTEVSAWLVHRDPDGSVSGTQPSAGIALENSGGLQDGTGPDGAVRESGAEQGFGEELEDLGAVAAPVNGDLTKEDIDLIDILWRQDIDLGAGREIFDYSHRQKESEVDKELSDGRERGDGWRSAGGQVTNRNLLVDGETGESFPAQVPGVEDQTALSLEECLRLLEATFPFGENSEFPAADVSTLSEAVPSESRPAGIQSSLLSPLLPETESPFDLEQQWQDLMSIMEMQAMEVNNTTAETLYNGTSGDLLTSNYNLAPNTPINQNVSLHQASLGSCSQDFSLFSSEIESPSMGGSSALLQLAPDNSTGLNTTFSSTNFSGIFFPPQLNSTVNETAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSGHSPASLSSSEASSSSSSSSSSSSSSSSSSSSFSEEGAVGYSSDSENVDFEEAEGAVGYQPEYSKFCRMSYQDPSQLHYLPYLEHVGHNHTYNMAPGTLDPEEPKLPSVGKKSSKEKPSEFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKSKLLREKVEFLKSIRQMKQKVQNLYQEVFGRLRDENGQPYSPNQYALQYASDGSVILIPRTLADQQARRQERKQKDRRK

85.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make NFE2L1 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here