Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.

Belongs to the heat shock protein 70 family.

667 amino acids

MNAIKRLLPVSLFLYALFVVLLPFQARAKDDVENYGTVIGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFTDDERLIGDAAKNQIAANPTNTIFDIKRLIGLKFNDRSVQRDIKHLPFKVVDKDGKPVVQVKVKGEDRVFTPEEISGMILGKMKQIAEDYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKSDKEHQIIVYDLGGGTFDVSLLSIENGVFEVQATSGDTHLGGEDFDYKIVRQLIKTFKKKHGIDVSDNEKALAKLKREAEKAKRALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLEDAGLEKKDIDDFVLVGGSTRIPKVQQLLESFFNGKKASKGINPDEAVAYGAAVQAGVLSGEEGVEDIVLLDVNALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVQIKVYEGERAMSKDNNLLGKFELTGIPPAPRGIPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQDEIDRMVEEAEKFASEDAVLRTKIEARNKLENYAHSIKNQVEGDLAEKLEEEDKETLLDAANDTLEWLEDNFDSATTEEFEEKFEALSKTAYPITSKLYGGADGSAPVYDDDEDEDDDTDYFDDEL

73.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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