Description
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Family
Belongs to the Nth/MutY family.
Species
Encephalitozoon cuniculi (strain GB-M1)
Sequence
MGSASGEEREGPLGLYLEIKMQRKDIVSPVDTMGCSITPSCRTEEERRFHILVSLLLSSQTKDEVTYEAMARLRKLLPESAATDGEARGGLTIERVANSDVKHINECIKKVGFHNRKAANLKKIAEILREKGLPREMKDLISLPGIGNKMALLYMSHACNRTVGISVDTHVHRISNRIGLVRTRDVESTRRELERVVPRKEWKTINNILVGFGQTICVAKRPRCEECCIRGRCPSSLF
Simulated SDS-PAGE
![Western blot of NTH1 recombinant protein](/recombinant/NTH1-7.png)
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service