Plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues.

Belongs to the AP endonuclease 2 family.

542 amino acids

MNPFVNLFIQHSKKQIFLNNNKNNILLNFNSKLYSTITYKNNNNNNNNQIINNKTIMKRKNNEIIQTEEDDDNDNGGIHDCDSCDEVDNEEIIPESPPSKKLQQQQQQQQQQQSKLKPKQTSITDFFSPTVKTSKADKISPFFSNVNNASTTNTTTNNKNVNKKTTTTTTTKKRNNKDEENEDDNEEEEEEEEEEEDKKSKKKTTTTTTTTTTTAYKKKSSPKKKKVNPTENKFSTINYKDDQYVQKEEYSSSKKEKLENVKIGGHVSIKNGYPTLIQSVVAQGFKAVAFFTNPPRTWKHHTVKLDDSIKFKQSCKSLNFDVNCILPHGSYFLNLGSPNKENLQKSRDLMIHEMKNCEILGVKHFNFHPGSHLNEISESESIKIVAESLDYILERTKDVVAVIECTAGQGTNLGYTFEHLRDMIALVKDKTRVGVCLDTCHMFAAGYNISTKSNCDVIFQEFDKVVGFKYLKGVHLNDSKSTCGSKLDRHENIGKGHIGTPCFKYLVNDKRFQNIPMILETVGPYDQEVKLLYSFIEDDDKK

62 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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