Endonuclease mostly active on RNA and ssDNA, and to a lower extent, on dsDNA (PubMed:22506810, PubMed:23620482). Can cleave mismatch regions in heteroduplex DNA containing single base pair mismatches or insertion/deletion bases (PubMed:22506810). In contradiction with PubMed:22506810, cannot hydrolyze single-stranded DNA and does not cleave mismatches (PubMed:17651368).

Belongs to the nuclease type I family.

290 amino acids

MANQKGLHVVMMIITVWLLYAAPNIHGWGKEGHEIICKIAQTRLDETAAKAVKELLPESAEGDLSSLCLWADRVKFRYHWSSPLHYINTPDACSYQYNRDCKDESGEKGRCVAGAIYNYTTQLLSYKTAASSQSQYNLTEALLFVSHFMGDIHQPLHVSYASDKGGNTIEVHWYTRKANLHHIWDSNIIETAEADLYNSALEGMVDALKKNITTEWADQVKRWETCTKKTACPDIYASEGIQAACDWAYKGVTEGDTLEDEYFYSRLPIVYQRLAQGGVRLAATLNRIFG

32.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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