Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

748 amino acids

MTISSFLRVRHSLAAAKCVLENAKQSFSSHAAFAEHAKLERIRNIGISAHIDSGKTTLTERILFYTGRIKQMHEVKGKDNVGATMDSMELERQRGITIQSAATYTMWKDHNINIIDTPGHVDFTVEVERALRVLDGAILVLCSVGGVQSQTLTVNRQMKRYNVPCLAFINKLDRTGANPYRVLGQMRSKLNHNAAFIQLPIGVESNCKGIVDLVKQRALYFEDHLGLTVREDEIPQEMRAESDERRHELIEHLSNVDESIGELFLEEKTPTEQDIMAAIRRSALKRTFTPVLVGTALKNKGVQPLLDAVLNYLPHPGEVENIALIEKKGKEPQQIMLDPARDGKSPFVGLAFKLEAGRFGQLTYLRCYQGVLRKGDSIFNVRSGKKVRLARLVRLHSNNMEDVNEVYAGDIFALFGVDCASGDTFVTNPDLELSMESIFVPDPVVSMAIKPANNKDRDNFSKAVARFTKEDPTFRFAYDTDIKETLVSGMGELHLEIYAQRMEREYNCPVILGKPKVAFRETLVAPCEFDFLHKKQSGGQGQYARVTGVLEPLPPHQNTTIEFTDETVGTNVPKQFVPGIEKGFRQMAEKGLLSGHKLSGIKFRLQDGAHHIVDSSELAFMLAAQGAIKSVFENGSWQILEPIMMVEVTAPEEFQGTVIGQLNKRHGIITGTEGSEGWFTVYAEVPLNDMFGYAGELRSSTQGKGEFSMEYSRYSPCKPDVQEKLMQDYQIAQGNVVVDAKKQQKKKN

83.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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